Article
Mitochondrial Ca2+ homeostasis in lysosomal storage diseases.
Cell calcium - 1 Jul 2008
Kiselyov Kirill, Muallem Shmuel
Abstract excerpt
Lysosomal storage diseases (LSDs) are a class of genetic disorders in which proteins responsible for digestion or absorption of endocytosed material do not function or do not localize properly. The resulting cellular "indigestion" causes buildup of intracellular storage inclusions that contain unprocessed lipids and proteins that form macromolecular complexes. The buildup of storage material is associated with...
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