Article

Modulation of lysosomal Cl <sup>-</sup> mediates migration and apoptosis through the TRPML1 as a lysosomal Cl <sup>-</sup> sensor

2022-12-23

Abstract excerpt

Lysosomes are responsible for protein degradation and clearance in cellular recycling centers. It has been known that the lysosomal chloride level is enriched and involved in intrinsic lysosomal function. However, the mechanism by which chloride levels can be sensed and the chloride-mediated lysosomal function is unknown. In this study, we verified that reduced chloride levels acutely induced lysosomal calcium rel...

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Literature Corpus work: a9a955dd-0442-5b2b-ab32-2578c59069bd
DOI: 10.1101/2022.12.23.521794

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