Article

TRPML1 : role in autophagy and potential target to treat lysosomal storage disorders

2018-01-01

Abstract excerpt

The view of the lysosome as the terminal end of cellular catabolic pathways has been challenged by recent studies showing a central role of this organelle in the control of cell function. Here we show that a lysosomal Ca2+ signaling mechanism controls the activities of the phosphatase calcineurin and of its substrate TFEB, a master transcriptional regulator of lysosomal biogenesis and autophagy. Lysosomal Ca2+ rel...

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Literature Corpus work: 8d9264ca-e8ae-533b-ab2a-b8dd3c6d991a
DOI: 10.21954/ou.ro.0000d800

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