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Lysosomal quality control Review

19 Feb 2025

Abstract excerpt

Healthy cells need functional lysosomes to degrade cargo delivered by autophagy and endocytosis. Defective lysosomes can lead to severe conditions such as lysosomal storage diseases (LSDs) and neurodegeneration. To maintain lysosome integrity and functionality, cells have evolved multiple quality control pathways corresponding to different types of stress and damage. These can be divided into five levels:...

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PMID: 39968899
DOI: 10.1080/15548627.2025.2469206

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