Article

Molecular simulations reveal the impact of RAMP1 on ligand binding and dynamics of CGRPR heterodimer

2021-05-10

Abstract excerpt

<h4>ABSTRACT</h4> The release of the neuropeptide of calcitonin gene-related peptide (CGRP) plays a key role in the mechanisms of migraine pathology and pain perception as it causes vasodilatation, neurogenic inflammation, mast cell degranulation, sensory signal activation and peripheral sensitivity. Although the findings on the effectiveness of CGRP-targeted therapies in migraine provide new information about th...

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Literature Corpus work: 5ce3fb6e-ff4d-50d9-9998-ad13ba843c36
DOI: 10.1101/2021.05.10.443383

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