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Article

Key Interaction Changes Determine the Activation Process of Human Parathyroid Hormone Type 1 Receptor.

Journal of the American Chemical Society - 29 Jan 2025

Zhang Yue, Zheng Qingchuan, Warshel Arieh, Bai Chen

Abstract excerpt

The parathyroid hormone type 1 receptor (PTH1R) plays a crucial role in modulating various physiological functions and is considered an effective therapeutic target for osteoporosis. However, a lack of detailed molecular and energetic information about PTH1R limits our comprehensive understanding of its activation process. In this study, we performed computational simulations to explore key events in the...

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Guanosine Diphosphate
Kinetics
Molecular Dynamics Simulation
Mutation
Protein Conformation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Receptor, Parathyroid Hormone, Type 1

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PMID: 39804793
DOI: 10.1021/jacs.4c15025
PMCID: PMC12452705

Genes

PTH1R

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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