Article
Unraveling the connection between calreticulin and myeloproliferative neoplasms via calcium signaling.
Cell biology international - 1 Jul 2023
Jaiswal Amit, Wang Zhiguo, Xudong Zhu, Ju Zhenyu
Abstract excerpt
Mutations in the form of insertions and deletions (INDEL) in the calreticulin gene lead to essential thrombocythemia (ET) which is characterized by the formation of thrombosis. However, the connection between calreticulin INDEL and ET remains largely elusive. Through combined molecular dynamics simulation, clustered regularly interspaced short palindromic repeats (CRISPR) and calcium imaging studies on the wild...
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