Article
Diminished allergic disease in patients with STAT3 mutations reveals a role for STAT3 signaling in mast cell degranulation.
The Journal of allergy and clinical immunology - 1 Dec 2013
Siegel Andrea M, Stone Kelly D, Cruse Glenn, Lawrence Monica G, Olivera Ana, Jung Mi-yeon, Barber John S, Freeman Alexandra F, Holland Steven M, O'Brien Michelle, Jones Nina, Nelson Celeste G, Wisch Laura B, Kong Heidi H, Desai Avanti, Farber Orly, Gilfillan Alasdair M, Rivera Juan, Milner Joshua D
Abstract excerpt
BACKGROUND: Severe atopic conditions associated with elevated serum IgE are heterogeneous with few known causes. Nearly every patient with autosomal-dominant hyper-IgE syndrome (AD-HIES) due to signal transducer and activator of transcription 3 (STAT3) mutations has a history of eczematous dermatitis and elevated IgE; however, clinical atopy has never been systematically studied. OBJECTIVE: Understanding of...
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