Article
A mouse model of HIES reveals pro- and anti-inflammatory functions of STAT3.
Blood - 8 May 2014
Steward-Tharp Scott M, Laurence Arian, Kanno Yuka, Kotlyar Alex, Villarino Alejandro V, Sciume Giuseppe, Kuchen Stefan, Resch Wolfgang, Wohlfert Elizabeth A, Jiang Kan, Hirahara Kiyoshi, Vahedi Golnaz, Sun Hong-Wei, Feigenbaum Lionel, Milner Joshua D, Holland Steven M, Casellas Rafael, Powrie Fiona, O'Shea John J
Abstract excerpt
Mutations of STAT3 underlie the autosomal dominant form of hyperimmunoglobulin E syndrome (HIES). STAT3 has critical roles in immune cells and thus, hematopoietic stem cell transplantation (HSCT), might be a reasonable therapeutic strategy in this disease. However, STAT3 also has critical functions in nonhematopoietic cells and dissecting the protean roles of STAT3 is limited by the lethality associated with...
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