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Cutting Edge: Genetic Variation Influences FcεRI-Induced Mast Cell Activation and Allergic Responses

1 Jul 2007

Abstract excerpt

Mast cell responses are influenced by a diverse array of environmental factors, but little is known about the effect of genetic background. In this study, we report that 129/Sv mice had high levels of circulating IgE, increased expression of the high-affinity receptor for IgE (Fc epsilonRI), and greater sensitivity to anaphylaxis when compared with C57BL/6 mice. Bone marrow-derived mast cells (BMMCs) from 129/Sv...

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PMID: 17617561
DOI: 10.4049/jimmunol.179.2.740

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