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Article

A Mouse Homolog of a Human TP53 Germline Mutation Reveals a Lipolytic Activity of p53.

Cell reports - 21 Jan 2020

Kang Ju-Gyeong, Lago Cory U, Lee Ji-Eun, Park Ji-Hoon, Donnelly Matthew P, Starost Matthew F, Liu Chengyu, Kwon Jaeyul, Noguchi Audrey C, Ge Kai, Wang Ping-Yuan, Hwang Paul M

Abstract excerpt

The physiological effects of the many germline mutations of TP53, encoding the tumor suppressor protein p53, are poorly understood. Here we report generating a p53 R178C knockin mouse modeling the human TP53 R181C mutation, which is notable for its prevalence and prior molecular characterization. Consistent with its weak cancer penetrance in humans, homozygous p53178C/C mice show a modest increase in...

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Identifiers

PMID: 31968253
DOI: 10.1016/j.celrep.2019.12.074
PMCID: PMC7021448

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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