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Article

Associations of TP53 codon 72 polymorphism with complications and comorbidities in patients with type 1 diabetes.

Journal of molecular medicine (Berlin, Germany) - 1 May 2021

Słomiński Bartosz, Skrzypkowska Maria, Ryba-Stanisławowska Monika, Myśliwiec Małgorzata, Trzonkowski Piotr

Abstract excerpt

Wild-type TP53 plays an important role in the regulation of immune response and systemic inflammation. In type 1 diabetes (T1D), TP53 pathways are upregulated and an increased susceptibility to apoptosis is observed. We hypothesize that TP53 codon 72 polymorphism could be associated with complications and comorbidities in patients with T1D. We have investigated the associations of the TP53 codon 72 polymorphism...

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Identifiers

PMID: 33495869
DOI: 10.1007/s00109-020-02035-1
PMCID: PMC8055568

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