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Article

Targeting PSAT1 to mitigate metastasis in tumors with p53-72Pro variant.

Signal transduction and targeted therapy - 15 Feb 2023

Jiang Jingwen, Chen Hai-Ning, Jin Ping, Zhou Li, Peng Liyuan, Huang Zhao, Qin Siyuan, Li Bowen, Ming Hui, Luo Maochao, Xie Na, Gao Wei, Nice Edouard C, Yu Qiang, Huang Canhua

Abstract excerpt

The single-nucleotide polymorphism (SNP) of p53, in particular the codon 72 variants, has recently been implicated as a critical regulator in tumor progression. However, the underlying mechanism remains elusive. Here we found that cancer cells carrying codon 72-Pro variant of p53 showed impaired metastatic potential upon serine supplementation. Proteome-wide mapping of p53-interacting proteins uncovered a...

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Share to Carcinoma, Hepatocellular
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36788227
DOI: 10.1038/s41392-022-01266-7
PMCID: PMC9929071

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