Article
The role of the p53 tumor suppressor in metabolism and diabetes.
The Journal of endocrinology - 1 Nov 2016
Kung Che-Pei, Murphy Maureen E
Abstract excerpt
In the context of tumor suppression, p53 is an undisputedly critical protein. Functioning primarily as a transcription factor, p53 helps fend off the initiation and progression of tumors by inducing cell cycle arrest, senescence or programmed cell death (apoptosis) in cells at the earliest stages of precancerous development. Compelling evidence, however, suggests that p53 is involved in other aspects of human...
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