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Article

Improving the reproducibility of the NAP1/B1/027 epidemic strain R20291 in the hamster model of infection.

Anaerobe - 1 Jun 2016

Kelly Michelle L, Ng Yen Kuan, Cartman Stephen T, Collery Mark M, Cockayne Alan, Minton Nigel P

Abstract excerpt

Comparative analysis of the Clostridium difficile BI/NAP1/027 strain R20291 and ClosTron-derived ermB mutants in the hamster infection model are compromised by the clindamycin susceptibility of the parent. Mutants can appear more virulent. We have rectified this anomaly by genome engineering. The variant created (CRG20291) represents an ideal control strain for virulence assays of ClosTron mutants.

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Identifiers

PMID: 26946361
DOI: 10.1016/j.anaerobe.2016.02.011
PMCID: PMC4879870

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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