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What's a SNP between friends: The influence of single nucleotide polymorphisms on virulence and phenotypes of Clostridium difficile strain 630 and derivatives.

Virulence - 18 Aug 2017

Collery Mark M, Kuehne Sarah A, McBride Shonna M, Kelly Michelle L, Monot Marc, Cockayne Alan, Dupuy Bruno, Minton Nigel P

Abstract excerpt

Clostridium difficile is a major cause of antibiotic induced diarrhea worldwide, responsible for significant annual mortalities and represents a considerable economic burden on healthcare systems. The two main C. difficile virulence factors are toxins A and B. Isogenic toxin B mutants of 2 independently isolated erythromycin-sensitive derivatives (630E and 630Δerm) of strain 630 were previously shown to exhibit...

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Identifiers

PMID: 27652799
DOI: 10.1080/21505594.2016.1237333
PMCID: PMC5626343

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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