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Importance of Toxin A, Toxin B, and CDT in Virulence of an Epidemic Clostridium difficile Strain

8 Aug 2013

Abstract excerpt

Clostridium difficile infection is the main cause of healthcare-acquired diarrhea in the developed world. In addition to the main virulence factors toxin A and B, epidemic, PCR Ribotype 027 strains, such as R20291, produce a third toxin, CDT. To develop effective medical countermeasures, it is important to understand the importance of each toxin. Accordingly, we created all possible combinations of isogenic toxin...

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PMID: 23935202
DOI: 10.1093/infdis/jit426

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