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Article

Endothelial Cullin3 Mutation Impairs Nitric Oxide-Mediated Vasodilation and Promotes Salt-Induced Hypertension.

Function (Oxford, England) - 1 Jan 2022

Wu Jing, Fang Shi, Lu Ko-Ting, Kumar Gaurav, Reho John J, Brozoski Daniel T, Otanwa Adokole J, Hu Chunyan, Nair Anand R, Wackman Kelsey K, Agbor Larry N, Grobe Justin L, Sigmund Curt D

Abstract excerpt

Human hypertension caused by in-frame deletion of CULLIN3 exon-9 (Cul3∆9) is driven by renal and vascular mechanisms. We bred conditionally activatable Cul3∆9 transgenic mice with tamoxifen-inducible Tie2-CREERT2 mice to test the importance of endothelial Cul3. The resultant mice (E-Cul3∆9) trended towards elevated nighttime blood pressure (BP) correlated with increased nighttime activity, but displayed no...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35493997
DOI: 10.1093/function/zqac017
PMCID: PMC9045850

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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