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Article

Polymorphisms in Plasmodium vivax Circumsporozoite Protein (CSP) Influence Parasite Burden and Cytokine Balance in a Pre-Amazon Endemic Area from Brazil.

PLoS neglected tropical diseases - 1 Mar 2016

Ribeiro Bruno de Paulo, Cassiano Gustavo Capatti, de Souza Rodrigo Medeiros, Cysne Dalila Nunes, Grisotto Marcos Augusto Grigolin, de Azevedo dos Santos Ana Paula Silva, Marinho Cláudio Romero Farias, Machado Ricardo Luiz Dantas, Nascimento Flávia Raquel Fernandes

Abstract excerpt

Mechanisms involved in severe P. vivax malaria remain unclear. Parasite polymorphisms, parasite load and host cytokine profile may influence the course of infection. In this study, we investigated the influence of circumsporozoite protein (CSP) polymorphisms on parasite load and cytokine profile in patients with vivax malaria. A cross-sectional study was carried out in three cities: São Luís, Cedral and...

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Identifiers

PMID: 26943639
DOI: 10.1371/journal.pntd.0004479
PMCID: PMC4778932

Genes

TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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