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A naturally occurring Vif mutant (I107T) attenuates anti-APOBEC3G activity and HIV-1 replication.

Journal of molecular biology - 23 Aug 2013

Peng Jinyu, Ao Zhujun, Matthews Chris, Wang Xiaoxia, Ramdahin Sue, Chen Xi, Li Junhua, Chen Liyu, He Jianmei, Ball Blake, Fowke Keith, Plummer Frank, Embree Joanne, Yao Xiaojian

Abstract excerpt

The human immunodeficiency virus type 1 (HIV-1) Vif protein counteracts the antiviral activity of the apolipoprotein B mRNA editing enzyme catalytic polypeptide-like 3 (APOBEC3) family of proteins by targeting the proteins for degradation through the ubiquitin-proteasome pathway. Previous mutagenic studies have shown that multiple domains of Vif are required for interacting with APOBEC3G proteins and the...

Topics

APOBEC-3G Deaminase
Cytidine Deaminase
Genetic Variation
HIV Infections
HIV Long-Term Survivors
HIV-1
Humans
Kenya
Mutant Proteins
Mutation, Missense

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Proteolysis

Virus Replication

vif Gene Products, Human Immunodeficiency Virus

Source

Identifiers

PMID: 23707381
DOI: 10.1016/j.jmb.2013.05.015

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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A naturally occurring Vif mutant (I107T) attenuates anti-APOBEC3G activity and HIV-1 replication.PMID 23707381Read ↗

Differential anti-APOBEC3G activity of HIV-1 Vif proteins derived from different subtypes.Semantic proximity Read ↗

Natural Variation in Vif: Differential Impact on APOBEC3G/3F and a Potential Role in HIV-1 DiversificationSemantic proximity Read ↗

Vif overcomes the innate antiviral activity of APOBEC3G by promoting its degradation in the ubiquitin-proteasome pathway.Semantic proximity Read ↗

A single amino acid substitution in human APOBEC3G antiretroviral enzyme confers resistance to HIV-1 virion infectivity factor-induced depletion.Semantic proximity Read ↗

Multifaceted counter-APOBEC3G mechanisms employed by HIV-1 Vif.Semantic proximity Read ↗

Identification of dominant negative human immunodeficiency virus type 1 Vif mutants that interfere with the functional inactivation of APOBEC3G by virus-encoded Vif.Semantic proximity Read ↗

Role of APOBEC3F Gene Variation in HIV-1 Disease Progression and Pneumocystis Pneumonia.Semantic proximity Read ↗

The Activity Spectrum of Vif from Multiple HIV-1 Subtypes against APOBEC3G, APOBEC3F, and APOBEC3HSemantic proximity Read ↗

Distinct Determinants in HIV-1 Vif and Human APOBEC3 Proteins Are Required for the Suppression of Diverse Host Anti-Viral ProteinsSemantic proximity Read ↗

APOBEC3B and APOBEC3C are potent inhibitors of simian immunodeficiency virus replication.Semantic proximity Read ↗

Inhibition of Vif-Mediated Degradation of APOBEC3G through Competitive Binding of Core-Binding Factor Beta.Semantic proximity Read ↗

Characterization of conserved motifs in HIV-1 Vif required for APOBEC3G and APOBEC3F interaction.Semantic proximity Read ↗

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