Article
Integrative Genomic Analysis of Pediatric Myeloid-Related Acute Leukemias Identifies Novel Subtypes and Prognostic Indicators.
Blood cancer discovery - 1 Nov 2021
Fornerod Maarten, Ma Jing, Noort Sanne, Liu Yu, Walsh Michael P, Shi Lei, Nance Stephanie, Liu Yanling, Wang Yuanyuan, Song Guangchun, Lamprecht Tamara, Easton John, Mulder Heather L, Yergeau Donald, Myers Jacquelyn, Kamens Jennifer L, Obeng Esther A, Pigazzi Martina, Jarosova Marie, Kelaidi Charikleia, Polychronopoulou Sophia, Lamba Jatinder K, Baker Sharyn D, Rubnitz Jeffrey E, Reinhardt Dirk, van den Heuvel-Eibrink Marry M, Locatelli Franco, Hasle Henrik, Klco Jeffery M, Downing James R, Zhang Jinghui, Pounds Stanley, Zwaan C Michel, Gruber Tanja A
Abstract excerpt
Genomic characterization of pediatric patients with acute myeloid leukemia (AML) has led to the discovery of somatic mutations with prognostic implications. Although gene-expression profiling can differentiate subsets of pediatric AML, its clinical utility in risk stratification remains limited. Here, we evaluate gene expression, pathogenic somatic mutations, and outcome in a cohort of 435 pediatric patients with...
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