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Article

Effects of 22 CYP2D6 Genetic Variations Newly Identified in Chinese Population on Olanzapine Metabolism in vitro.

Pharmacology - 1 Jan 2016

Zhou Hong-Yu, Gu Er-Min, Chen Qiu-Lei, Zhan Yun-Yun, Wang Shuang-Hu, Liang Bing-Qing, Dai Da-Peng, Cai Jian-Ping, Hu Guo-Xin

Abstract excerpt

The objective of this study was to assess the catalytic activity of 22 novel CYP2D6 allelic variants (2D6*87-*98, R25Q, F164L, E215K, F219S, V327M, D336N, V342M, R344Q, R440C and R497C) to olanzapine in vitro. Their protein products expressed in Spodoptera frugiperda 21 (Sf21) insect cells were incubated with olanzapine 100-2,000 μmol/l for 30 min. The kinetic parameters of Km, Vmax and intrinsic clearance were...

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Identifiers

PMID: 27251229
DOI: 10.1159/000446807

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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