Article
Biological significance of FoxN1 gain-of-function mutations during T and B lymphopoiesis in juvenile mice.
Cell death & disease - 9 Oct 2014
Ruan L, Zhang Z, Mu L, Burnley P, Wang L, Coder B, Zhuge Q, Su D-M
Abstract excerpt
FoxN1 is cell-autonomously expressed in skin and thymic epithelial cells (TECs), essential for their development. Inborn mutation of FoxN1 results in hair follicle and TEC development failure, whereas insufficient postnatal FoxN1 expression induces thymic atrophy, resulting in declined T lymphopoiesis. Although upregulating FoxN1 expression in the aged FoxN1-declined thymus rejuvenates T lymphopoiesis, whether...
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