Article
FOXN1 mutation abrogates prenatal T-cell development in humans.
Journal of medical genetics - 1 Jun 2011
Vigliano I, Gorrese M, Fusco A, Vitiello L, Amorosi S, Panico L, Ursini M V, Calcagno G, Racioppi L, Del Vecchio L, Pignata C
Abstract excerpt
BACKGROUND: The transcription factor FOXN1 is implicated in the differentiation of thymic and skin epithelial cells, and alterations in it are responsible for the Nude/SCID phenotype. During a genetic counselling programme offered to couples at risk in a community where a high frequency of mutated FOXN1 had been documented, the identification of a human FOXN1(-/-) fetus gave the unique opportunity to study T cell...
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