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Article

Disruption of FGF5 in Cashmere Goats Using CRISPR/Cas9 Results in More Secondary Hair Follicles and Longer Fibers.

PloS one - 1 Jan 2016

Wang Xiaolong, Cai Bei, Zhou Jiankui, Zhu Haijing, Niu Yiyuan, Ma Baohua, Yu Honghao, Lei Anmin, Yan Hailong, Shen Qiaoyan, Shi Lei, Zhao Xiaoe, Hua Jinlian, Huang Xingxu, Qu Lei, Chen Yulin

Abstract excerpt

Precision genetic engineering accelerates the genetic improvement of livestock for agriculture and biomedicine. We have recently reported our success in producing gene-modified goats using the CRISPR/Cas9 system through microinjection of Cas9 mRNA and sgRNAs targeting the MSTN and FGF5 genes in goat embryos. By investigating the influence of gene modification on the phenotypes of Cas9-mediated goats, we herein...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27755602
DOI: 10.1371/journal.pone.0164640
PMCID: PMC5068700

Genes

FGF5
MSTN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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