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Article

Informed clinical decisions by outfoxing human FOXN1 variants.

The Journal of allergy and clinical immunology - 1 Oct 2025

Wysocki Christian A, van Oers Nicolai S C

Abstract excerpt

Thymic T-cell development is orchestrated by thymic epithelial cells. The master transcriptional regulator of these cells is forkhead box N1 (FOXN1), which controls their differentiation, expansion, and function. Biallelic founder mutations in FOXN1 caused a nude/severe combined immunodeficiency phenotype due to congenital thymic aplasia and alopecia universalis. This established the critical role of FOXN1 in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40484290
DOI: 10.1016/j.jaci.2025.05.025
PMCID: PMC13430552

Genes

FOXN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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