Article
Analysis of the evolution of resistance to multiple antibiotics enables prediction of the Escherichia coli phenotype-based fitness landscape.
PLoS biology - 1 Dec 2022
Iwasawa Junichiro, Maeda Tomoya, Shibai Atsushi, Kotani Hazuki, Kawada Masako, Furusawa Chikara
Abstract excerpt
The fitness landscape represents the complex relationship between genotype or phenotype and fitness under a given environment, the structure of which allows the explanation and prediction of evolutionary trajectories. Although previous studies have constructed fitness landscapes by comprehensively studying the mutations in specific genes, the high dimensionality of genotypic changes prevents us from developing a...
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