Article
Spatial genomic heterogeneity within localized, multifocal prostate cancer.
Nature genetics - 1 Jul 2015
Boutros Paul C, Fraser Michael, Harding Nicholas J, de Borja Richard, Trudel Dominique, Lalonde Emilie, Meng Alice, Hennings-Yeomans Pablo H, McPherson Andrew, Sabelnykova Veronica Y, Zia Amin, Fox Natalie S, Livingstone Julie, Shiah Yu-Jia, Wang Jianxin, Beck Timothy A, Have Cherry L, Chong Taryne, Sam Michelle, Johns Jeremy, Timms Lee, Buchner Nicholas, Wong Ada, Watson John D, Simmons Trent T, P'ng Christine, Zafarana Gaetano, Nguyen Francis, Luo Xuemei, Chu Kenneth C, Prokopec Stephenie D, Sykes Jenna, Dal Pra Alan, Berlin Alejandro, Brown Andrew, Chan-Seng-Yue Michelle A, Yousif Fouad, Denroche Robert E, Chong Lauren C, Chen Gregory M, Jung Esther, Fung Clement, Starmans Maud H W, Chen Hanbo, Govind Shaylan K, Hawley James, D'Costa Alister, Pintilie Melania, Waggott Daryl, Hach Faraz, Lambin Philippe, Muthuswamy Lakshmi B, Cooper Colin, Eeles Rosalind, Neal David, Tetu Bernard, Sahinalp Cenk, Stein Lincoln D, Fleshner Neil, Shah Sohrab P, Collins Colin C, Hudson Thomas J, McPherson John D, van der Kwast Theodorus, Bristow Robert G
Abstract excerpt
Herein we provide a detailed molecular analysis of the spatial heterogeneity of clinically localized, multifocal prostate cancer to delineate new oncogenes or tumor suppressors. We initially determined the copy number aberration (CNA) profiles of 74 patients with index tumors of Gleason score 7. Of these, 5 patients were subjected to whole-genome sequencing using DNA quantities achievable in diagnostic biopsies,...
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