Article
Determinants of widespread metastases and of metastatic tropism in patients with prostate cancer: A genomic analysis of primary and metastatic tumors.
Urologic oncology - 1 May 2023
Alshalalfa Mohammed, Goglia Alexander G, Swami Nishwant, Nguyen Bastien, Hougen Helen Y, Khan Anwar, Kishan Amar U, Punnen Sanoj, Nguyen Paul L, Mahal Brandon A, Dee Edward Christopher
Abstract excerpt
INTRODUCTION: Emerging evidence suggests that metastasis is better described as a spectrum of disease rather than a binary state. A greater understanding of the genomic features that determine extent and location of metastatic spread may inform risk stratification and monitoring. Here, we identify genomic alterations from primary prostate carcinomas that are predictive of wide-spread metastatic potential....
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