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Article

Pharmacogenetic aspects of tramadol pharmacokinetics and pharmacodynamics after a single oral dose.

Forensic science international - 1 May 2014

Bastami Salumeh, Haage Pernilla, Kronstrand Robert, Kugelberg Fredrik C, Zackrisson Anna-Lena, Uppugunduri Srinivas

Abstract excerpt

The major purpose of this study was to elucidate if genotyping can facilitate interpretations of tramadol (TRA) in forensic case work, with special regard to the estimation of the time of drug intake and drug related symptoms (DRS). The association between genetic polymorphisms in CYP2D6, OPRM1 and ABCB1 and pharmacokinetic and pharmacodynamic properties of TRA was studied. Nineteen healthy volunteers were...

Read the complete abstract on PubMed

Topics

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Share to Administration, Oral
Share to Analgesics, Opioid

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to ATP Binding Cassette Transporter, Subfamily B

Share to Cytochrome P-450 CYP2D6

Share to Forensic Genetics

Share to Mass Spectrometry

Share to Random Allocation

Share to Receptors, Opioid, mu

Source

Identifiers

PMID: 24709712
DOI: 10.1016/j.forsciint.2014.03.003

Genes

TRA
ABCB1
OPRM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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