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Article

Tramadol-Related Deaths: Genetic Analysis in Relation to Metabolic Ratios.

Journal of analytical toxicology - 13 Aug 2022

Aly Sanaa M, Tartar Océane, Sabaouni Naoual, Hennart Benjamin, Gaulier Jean-Michel, Allorge Delphine

Abstract excerpt

Tramadol (TR) metabolism is mainly dependent on the enzymatic activity of CYP2D6, which is controlled by genetic polymorphisms. Individuals are classified as poor (PMs), intermediate (IMs), extensive (EMs) or ultrarapid metabolizers (UMs) according to their genotype or phenotype. The determination of the metabolic phenotype for CYP2D6 can be of utmost importance in forensic and clinical contexts that involve TR...

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PMID: 34480795
DOI: 10.1093/jat/bkab096

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