Oxycodone findings and CYP2D6 function in postmortem cases.

doi:10.1016/j.fsigen.2021.102510

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Article

Oxycodone findings and CYP2D6 function in postmortem cases.

Forensic science international. Genetics - 1 Jul 2021

Jakobsson Gerd, Larsson Ronja, Pellè Lucia, Kronstrand Robert, Gréen Henrik

Abstract excerpt

Genetic disposition can cause variation in oxycodone pharmacokinetic characteristics and decrease or increase the expected clinical response. In forensic medicine, determination of cause of death or assessing time between drug intake and death can be facilitated by knowledge of parent and metabolite concentrations. In this study, the aim was to investigate if CYP2D6 genotyping can facilitate interpretation by...

Topics

Adolescent
Adult
Aged
Analgesics, Opioid
Cytochrome P-450 CYP2D6
DNA Copy Number Variations
Female
Forensic Genetics
Genotype
High-Throughput Nucleotide Sequencing
Humans
Male
Middle Aged
Morphinans
Oxycodone
Pharmacogenomic Testing
Phenotype
Polymorphism, Single Nucleotide

Source

Open in PubMed

Identifiers

PMID: 33799050
DOI: 10.1016/j.fsigen.2021.102510

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