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Article

Male-specific association between MT-ND4 11719 A/G polymorphism and ulcerative colitis: a mitochondria-wide genetic association study.

BMC gastroenterology - 3 Oct 2016

Dankowski Theresa, Schröder Torsten, Möller Steffen, Yu Xinhua, Ellinghaus David, Bär Florian, Fellermann Klaus, Lehnert Hendrik, Schreiber Stefan, Franke Andre, Sina Christian, Ibrahim Saleh M, König Inke R

Abstract excerpt

BACKGROUND: Ulcerative colitis (UC) is a chronic inflammatory disorder of still unknown pathogenesis. Increasing evidence indicates that alterations in mitochondrial respiration and thus adenosine triphosphate (ATP) production are involved. This may contribute to mucosal energy deficiency and subsequently intestinal barrier malfunction, which is accepted to be a major hallmark of UC. Genetic alterations of the...

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Identifiers

PMID: 27716073
DOI: 10.1186/s12876-016-0509-1
PMCID: PMC5048482

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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