Article
Assessment of the Changes in Mitochondrial Gene Polymorphism in Ulcerative Colitis and the Etiology of Ulcerative Colitis-associated Colorectal Cancer.
Anticancer research - 1 Jan 2020
Tanaka Toshiaki, Kobunai Takashi, Yamamoto Yoko, Murono Koji, Emoto Shigenbu, Hiyoshi Masaya, Kaneko Manabu, Sasaki Kazuhito, Shuno Yasutaka, Nishikawa Takeshi, Hata Keisuke, Kawai Kazushige, Nozawa Hiroaki, Ishihara Soichiro
Abstract excerpt
BACKGROUND: Mitochondria are energy-producing organelles, and dysfunction in these organelles causes various types of disease. Although several studies have identified mutations in nuclear DNA that are associated with the etiology of ulcerative colitis (UC), information regarding mitochondrial DNA (mtDNA) in UC is limited. This study aimed to investigate the mitochondrial DNA polymorphism underlying the etiology...
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