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The 7436-bp mitochondrial DNA deletion as a risk factor for ulcerative colitis in the Iranian population.

Nucleosides, nucleotides & nucleic acids - 1 Jan 2026

Zahmatkesh Roodsari Rasoul, Salehi Zivar, Parivar Kazem, Mashayekhi Farhad, Aminian Keyvan

Abstract excerpt

Ulcerative colitis (UC) is a chronic condition characterized by inflammation in the colon. Free radicals and oxidative stress play a significant role in the pathophysiology of UC. Excessive production of reactive oxygen species can damage the mitochondrial genome, leading to mutations such as the7436-bp deletion. The aim of this study was to identify the presence of the 7436-bp mtDNA deletion in patients with UC...

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Identifiers

PMID: 40132088
DOI: 10.1080/15257770.2025.2484317

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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