Article

Exome analysis of Indian ulcerative colitis reveals novel genes affecting epithelial integrity, DNA repair, trafficking, and immune signalling

2026-08-05

Abstract excerpt

The genetic component of ulcerative colitis (UC) remains largely unexplained in non-European populations. This study aimed to investigate the polygenic architecture of UC in an Indian population. Whole-exome sequencing was performed in 160 UC patients and 379 ethnically matched controls. Gene-based rare variant burden tests (SKAT-O, CMC) and exome-wide association testing of coding and noncoding common variants us...

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Literature Corpus work: 1ab55053-648b-5e16-8553-52b4e6d76125
DOI: 10.1186/s40246-026-00994-z

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