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Autophagy functions in programmed cell death

1 Apr 2008

Abstract excerpt

Autophagic cell death is a prominent morphological form of cell death that occurs in diverse animals. Autophagosomes are abundant during autophagic cell death, yet the functional role of autophagy in cell death has been enigmatic. We find that autophagy and the Atg genes are required for autophagic cell death of Drosophila salivary glands. Although caspases are present in dying salivary glands, autophagy is...

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PMID: 18212526
DOI: 10.4161/auto.5575

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