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Article

A genetic screen in Drosophila reveals novel cytoprotective functions of the autophagy-lysosome pathway.

PloS one - 29 Jun 2009

Arsham Andrew M, Neufeld Thomas P

Abstract excerpt

The highly conserved autophagy-lysosome pathway is the primary mechanism for breakdown and recycling of macromolecular and organellar cargo in the eukaryotic cell. Autophagy has recently been implicated in protection against cancer, neurodegeneration, and infection, and interest is increasing in additional roles of autophagy in human health, disease, and aging. To search for novel cytoprotective features of this...

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Identifiers

PMID: 19562034
DOI: 10.1371/journal.pone.0006068
PMCID: PMC2698153

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