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Article

Drosophila Rab39 Attenuates Lysosomal Degradation.

International journal of molecular sciences - 30 Sept 2021

Lakatos Zsolt, Benkő Péter, Juhász Gábor, Lőrincz Péter

Abstract excerpt

Lysosomal degradation, the common destination of autophagy and endocytosis, is one of the most important elements of eukaryotic metabolism. The small GTPases Rab39A and B are potential new effectors of this pathway, as their malfunction is implicated in severe human diseases like cancer and neurodegeneration. In this study, the lysosomal regulatory role of the single Drosophila Rab39 ortholog was characterized,...

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Identifiers

PMID: 34638976
DOI: 10.3390/ijms221910635
PMCID: PMC8508792

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