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Article

mTORC1 activation is not sufficient to suppress hepatic PPARα signaling or ketogenesis.

The Journal of biological chemistry - 1 Jul 2021

Selen Ebru S, Wolfgang Michael J

Abstract excerpt

The mechanistic target of rapamycin (mTOR) is often referred to as a master regulator of the cellular metabolism that can integrate the growth factor and nutrient signaling. Fasting suppresses hepatic mTORC1 activity via the activity of the tuberous sclerosis complex (TSC), a negative regulator of mTORC1, to suppress anabolic metabolism. The loss of TSC1 in the liver locks the liver in a constitutively anabolic...

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Identifiers

PMID: 34146544
DOI: 10.1016/j.jbc.2021.100884
PMCID: PMC8294577

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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