Article

Skeletal Muscle mTORC1 Activation Increases Energy Expenditure and Reduces Longevity in Mice

2019-07-31

Abstract excerpt

The mechanistic target of rapamycin (mTORC1) is a nutrient responsive protein kinase complex that helps co-ordinate anabolic processes across all tissues. There is evidence that signaling through mTORC1 in skeletal muscle may be a determinant of energy expenditure and aging and therefore components downstream of mTORC1 signaling may be potential targets for treating obesity and age-associated metabolic disease. He...

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Literature Corpus work: 934286b2-8baa-5fe1-926b-4142f798b012
DOI: 10.1101/720540

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