Article
Common ABCB1 polymorphisms in Greek patients with chronic hepatitis C infection: A comparison with hyperlipidemic patients and the general population.
Pharmacological reports : PR - 1 Apr 2016
Gbandi Emma, Goulas Antonis, Sevastianos Vassilios, Hadziyannis Stephanos, Panderi Athanasia, Koskinas John, Papatheodoridis George, Vasiliadis Themistoklis, Agapakis Dimitrios, Protopapas Andreas, Ioannidou Panagiota, Zacharakis George, Sinakos Emmanuil, Koutsounas Sotiris, Germanidis Georgios
Abstract excerpt
BACKGROUND: Hepatitis C virus infectivity and replication efficiency appears to be dependent on the lipid content and organization of the plasma membrane of the host cell, as well as of the intracellular membranous web. As there is increasing awareness of a role played by the efflux pump ABCB1 (p-glycoprotein, P-gp) in lipid homeostasis, its function could be a determinant of chronic HCV infection. The aim of the...
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