Article
A frequent variant in the human bile salt export pump gene ABCB11 is associated with hepatitis C virus infection, but not liver stiffness in a German population.
BMC gastroenterology - 8 Jun 2012
Müllenbach Roman, Weber Susanne N, Krawczyk Marcin, Zimmer Vincent, Sarrazin Christoph, Lammert Frank, Grünhage Frank
Abstract excerpt
BACKGROUND: The human ATP-binding cassette, subfamily B, member 11 (ABCB11) gene encodes the bile salt export pump, which is exclusively expressed at the canalicular membrane of hepatocytes. A frequent variant in the coding region, c.1331 T>C, leading to the amino acid exchange p.V444A, has been associated with altered serum bile salt levels in healthy individuals and predisposes homozygous carriers of the [C]...
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