Article
Prevalence of ABCB1 3435C>T polymorphism in the Cuban population.
Drug metabolism and personalized therapy - 6 Dec 2021
Rodeiro Guerra Idania, Herrea Jose, Cuétara Elizabeth, Garrido Gabino, Reyes Elizabeth, Martínez Ioanna, Pérez Carlos L, Fernández Gisselle, Hernández-Balmaseda Ivones, Delgado René, Stingl Julia C, Berghe Wim Vanden
Abstract excerpt
OBJECTIVES: ABCB1 gene polymorphisms can modify P-glycoprotein function with clinical consequences. METHODS: The 3435C>T polymorphism prevalence was analyzed using oligonucleotide probes and next-generation sequencing in 421 unrelated healthy individuals living in Cuba. Data were stratified by gender, ethnic background and residence. The genotype and allelic frequencies were determined. RESULTS: The genotype...
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