Article
A common polymorphism in the ABCB11 gene is associated with advanced fibrosis in hepatitis C but not in non-alcoholic fatty liver disease.
Clinical science (London, England : 1979) - 1 Apr 2011
Iwata Rika, Baur Katharina, Stieger Bruno, Mertens Joachim C, Daly Ann K, Frei Pascal, Braun Julia, Vergopoulos Athanasios, Stickel Felix, Sabrane Karim, Martin Ina V, Schmitt Johannes, Goetze Oliver, Day Chris P, Müllhaupt Beat, Geier Andreas
Abstract excerpt
Chronic HCV (hepatitis C virus)-associated cirrhosis represents a major indication for liver transplantation. Bile acids contribute to hepatic stellate cell activation as a key event in fibrogenesis. The aim of the present study was to investigate the role of bile acids and polymorphisms in bile acid level-regulating genes on fibrosis progression. A total of 206 subjects with chronic HCV infection were included...
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