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Article

Common ABCB4 and ABCB11 Genotypes Are Associated with Idiopathic Chronic Cholestasis in Adults.

Digestive diseases (Basel, Switzerland) - 1 Jan 2022

Jüngst Christoph, Justinger Christina, Fischer Janett, Berg Thomas, Lammert Frank

Abstract excerpt

INTRODUCTION: Pathogenic mutations in genes encoding the hepatocanalicular transporters ATP8B1, ABCB11 and ABCB4 are causative for progressive cholestatic liver disease in children. In adults, less severe variants such as the common ABCB4 c.711A>T polymorphism have been associated with intrahepatic cholestasis in pregnancy and elevated liver enzymes. Hence, our aim was to study the role of common polymorphisms in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 34348275
DOI: 10.1159/000518203

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