Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

MEF2D and MEF2C pathways disruption in sporadic and familial ALS patients.

Molecular and cellular neurosciences - 1 Jul 2016

Arosio Alessandro, Sala Gessica, Rodriguez-Menendez Virginia, Grana Denise, Gerardi Francesca, Lunetta Christian, Ferrarese Carlo, Tremolizzo Lucio

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a progressive neuro-muscular disease characterized by motor neuron loss. MEF2D and MEF2C are members of the myocyte enhancer factor 2 family (MEF2), a group of transcription factors playing crucial roles both in muscle and in neural development and maintenance; for this reason, a possible involvement of MEF2 in ALS context has been investigated. Since the transcriptional...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amyotrophic Lateral Sclerosis
Share to Brain-Derived Neurotrophic Factor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytoskeletal Proteins

Share to Histone Deacetylases

Share to MEF2 Transcription Factors

Share to Monocytes

Share to rab5 GTP-Binding Proteins

Share to Superoxide Dismutase-1

Source

Identifiers

PMID: 26921792
DOI: 10.1016/j.mcn.2016.02.002

Genes

SOD1
HDAC4
HDAC5
BDNF
KLF6
RUFY3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

MEF2D and MEF2C pathways disruption in sporadic and familial ALS patients.PMID 26921792Read ↗

Histone deacetylases and their role in motor neuron degenerationSemantic proximity Read ↗

Loss of MEF2C function by enhancer mutation leads to neuronal mitochondria dysfunction and motor deficits in miceSemantic proximity Read ↗

Molecular Alterations in Sporadic and SOD1-ALS Immortalized Lymphocytes: Towards a Personalized Therapy.Semantic proximity Read ↗

Histone Deacetylases: Molecular Mechanisms and Therapeutic Implications for Muscular DystrophiesSemantic proximity Read ↗

New Statement about NRF2 in Amyotrophic Lateral Sclerosis and Frontotemporal DementiaSemantic proximity Read ↗

Sex-specific risk loci and modified <i>MEF2C</i> expression in ALSSemantic proximity Read ↗

NR1D1 downregulation in astrocytes induces a phenotype that is detrimental to cocultured motor neurons.Semantic proximity Read ↗

Identification of a novel mutation in MEF2C gene in an atypical patient with frontotemporal lobar degeneration.Semantic proximity Read ↗

The anabolic/androgenic steroid nandrolone exacerbates gene expression modifications induced by mutant SOD1 in muscles of mice models of amyotrophic lateral sclerosis.Semantic proximity Read ↗

Differential Expression of Several miRNAs and the Host Genes AATK and DNM2 in Leukocytes of Sporadic ALS PatientsSemantic proximity Read ↗

MicroRNAs and HDAC4 protein expression in the skeletal muscle of ALS patientsSemantic proximity Read ↗

Association of NFE2L2 and KEAP1 haplotypes with amyotrophic lateral sclerosis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.