Article

Sex-specific risk loci and modified <i>MEF2C</i> expression in ALS

2024-05-27

Abstract excerpt

Significantly more men develop amyotrophic lateral sclerosis (ALS) than women, and heritability is not uniform between male and female transmissions, together suggesting a role for sex in the genetic aetiology of the disease. We therefore performed sex-stratified genome-wide and transcriptome-wide analyses of ALS risk, identifying six novel sex-specific risk loci including MEF2C , which shows increased expression...

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Literature Corpus work: 02759e93-deac-5b80-9eaa-98c4daceb2ce
DOI: 10.1101/2024.05.25.24307829

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