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Article

NR1D1 downregulation in astrocytes induces a phenotype that is detrimental to cocultured motor neurons.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Apr 2022

Killoy Kelby M, Harlan Benjamin A, Pehar Mariana, Vargas Marcelo R

Abstract excerpt

Nuclear receptor subfamily 1 group D member 1 (NR1D1, also known as Rev-erbα) is a nuclear transcription factor that is part of the molecular clock encoding circadian rhythms and may link daily rhythms with metabolism and inflammation. NR1D1, unlike most nuclear receptors, lacks a ligand-dependent activation function domain 2 and is a constitutive transcriptional repressor. Amyotrophic lateral sclerosis (ALS) is...

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Identifiers

PMID: 35319791
DOI: 10.1096/fj.202101275R
PMCID: PMC9223394

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