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Article

Molecular Alterations in Sporadic and SOD1-ALS Immortalized Lymphocytes: Towards a Personalized Therapy.

International journal of molecular sciences - 16 Mar 2021

Lastres-Becker Isabel, Porras Gracia, Arribas-Blázquez Marina, Maestro Inés, Borrego-Hernández Daniel, Boya Patricia, Cerdán Sebastián, García-Redondo Alberto, Martínez Ana, Martin-Requero Ángeles

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a fatal neurological condition where motor neurons (MNs) degenerate. Most of the ALS cases are sporadic (sALS), whereas 10% are hereditarily transmitted (fALS), among which mutations are found in the gene that codes for the enzyme superoxide dismutase 1 (SOD1). A central question in ALS field is whether causative mutations display selective alterations not found in sALS...

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PMID: 33809456
DOI: 10.3390/ijms22063007
PMCID: PMC8000750

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